A Practical Course in Differential Equations and Mathematical Modelling is a unique blend of the traditional methods of ordinary and partial differential equations with Lie group analysis enriched by the author's own theoretical developments. The book -- which aims to present new mathematical curricula based on symmetry and invariance principles -- is tailored to develop analytic skills and 'working knowledge' in both classical and Lie's methods for solving linear and nonlinear equations. This approach helps to make courses n differential equations, mathematical modelling, distributions and fundamental solution, etc. easy to follow and interesting for students. The book is based on the author'