A Practical Coursein Differential Equations and Mathematical Modelling is a uniqueblend of the traditional methods of ordinary and partialdifferential equations with Lie group analysis enriched by theauthor's own theoretical developments. The book -- which aims topresent new mathematical curricula based on symmetry and invarianceprinciples -- is tailored to develop analytic skills and 'workingknowledge' in both classical and Lie's methods for solving linearand nonlinear equations. This approach helps to make courses ndifferential equations, mathematical modelling, distributions andfundamental solution, etc. easy to follow and interesting forstudents. The book is based on the author's extensive teachingexperience at Novosibirsk and Moscow universities in Russia,College de France, Georgia Tech and Stanford University in theUnited States, universities in South Africa, Cyprus, Turkey, andBlekinge Institute of Technology (BTH) in Sweden. The newcurriculum prepares students for solving modern nonlinear problemsand will essentially be more appealing to students pared to thetraditional way of teaching mathematics. The book can be used as amain textbook by undergraduate and graduate students and universitylecturers in applied mathematics, physics andengineering.