Medical statistics is an applied science which combines theory of statistics with medical science. It is an indispensable theoretical science to conduct scientific research and a mandatory course for all medical majors in universities. Currently, although there are many publications about medical statistics and manuals of statistical software, most of the textbooks of medical statistics emphasize on the theoretical aspects and lack of straight and thorough introduction of statistical software. Also, most of the manuals of statistical software mainly focus on the introduction of the software while lack concepts and theory of statistics. This textbook combines statistical methods with the common manipulation of SPSS software, which makes up the shortcomings mentioned above.